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Effect of halogens on 3-[4-(dimethylamino) phenyl]-1-phenylprop-2-en-1-ones: development of a new class of monoamine oxidase-B inhibitors

Abstract Five dimethylamino-based chalcone derivatives (AC) were synthesized and evaluated for their inhibition degree against monoamine oxidase (MAO) enzymes. All AC compounds showed better inhibitory activity against MAO-B than that against MAO-A. AC4 showed the highest inhibitory ability with an...

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Principais autores: Haydara Ammar Hasan, Jiseong Lee, Sunil Kumar, Saleh Alfarraj, Sulaiman Ali Alharbi, Manu Pant, Hoon Kim, Bijo Mathew
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2024-08-01
Colecção:Applied Biological Chemistry
Assuntos:
Dimethylamine chalcones
Monoamine oxidase-B
Kinetics
Swiss target prediction
Molecular dynamics
Acesso em linha:https://doi.org/10.1186/s13765-024-00929-z
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