Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders

Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their inhibitory potential against monoamine oxidases (MAOs) and β-secretase (BACE-1). Six compounds inhibited MAO-B more effectively than MAO-A, and the...

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Główni autorzy:	Payyalot Koyiparambath Vishal, Jong Min Oh, Ahmed Khames, Mohamed A. Abdelgawad, Aathira Sujathan Nair, Lekshmi R. Nath, Nicola Gambacorta, Fulvio Ciriaco, Orazio Nicolotti, Hoon Kim, Bijo Mathew
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2021-06-01
Seria:	Pharmaceutics
Hasła przedmiotowe:	monoamine oxidase β-secretase chalcones reversibility cytotoxicity molecular docking
Dostęp online:	https://www.mdpi.com/1999-4923/13/6/850
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