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Loss of mitochondrial Ca2+ response and CaMKII/ERK activation by LRRK2R1441G mutation correlate with impaired depolarization-induced mitophagy

Abstract Background Stress-induced activation of ERK/Drp1 serves as a checkpoint in the segregation of damaged mitochondria for autophagic clearance (mitophagy). Elevated cytosolic calcium (Ca2+) activates ERK, which is pivotal to mitophagy initiation. This process is altered in Parkinson’s disease...

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Principais autores: Eunice Eun-Seo Chang, Huifang Liu, Zoe Yuen-Kiu Choi, Yasine Malki, Steffi Xi-Yue Zhang, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho, Philip Wing-Lok Ho
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-10-01
Serier:Cell Communication and Signaling
Fag:
Parkinson disease
LRRK2 mutation
Mitophagy
Calcium-dependent pathways
Mitochondrial dysfunction
Cellular stress response
Online adgang:https://doi.org/10.1186/s12964-024-01844-y
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