DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

Abstract Stress granules (SGs) and processing bodies (PBs), assembled via liquid-liquid phase separation (LLPS), are critical for spatial regulation of gene expression in the cytoplasm. However, their roles in tumorigenesis remain poorly understood. Here, we show DEAD-box helicase 6 (DDX6) as the mo...

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Autors principals:	Hongjie Bi, Wei Li, Lili Ren, Honghai Zhang, Lei Dong, Anthony Chan, Xueer Wang, Lu Yang, Xiaoxu Zhang, Meilin Xue, Hanjun Qin, Xiwei Wu, Johanna Ten Hoeve-Scott, Bin Zhang, Ling Li, Mark Wunderlich, James C. Mulloy, Steven T. Rosen, Jianjun Chen, Xiaobo Li, Chun-Wei Chen, Rui Su
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-66966-4
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