p53 downregulates the Fanconi anaemia DNA repair pathway
P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita. Here the authors show that increased p53 activity leads to the repression of telomere maintenance and DNA repair genes.
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2016-04-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/ncomms11091 |
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