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Chemoproteomics unveils Sofalcone targeting ribosomal proteins to inhibit protein synthesis in Staphylococcus aureus

Abstract The escalating threat of antibiotic resistance, particularly in Staphylococcus aureus (including methicillin-resistant strains, MRSA), underscores the urgent need for novel therapeutics. Sofalcone (Sof), a chalcone derivative from Sophora subprostrata with established anti-inflammatory and...

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Principais autores: Lirun Zhou, Ying Zhang, Ruishen Zhuge, Liqiong Wu, Zheng Chu, Ang Ma, Peng Gao, Yin Kwan Wong, Junzhe Zhang, Xin Peng, Peili Wang, Jigang Wang, Huan Tang
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2025-05-01
Serier:Molecular Biomedicine
Fag:
Sofalcone
Staphylococcus aureus
Chemoproteomics
Ribosomal proteins
Antibiotics
Drug-resistance
Online adgang:https://doi.org/10.1186/s43556-025-00269-4
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