NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

NMDA receptors (NMDARs) are widely distributed throughout the central nervous system (CNS) and play pivotal roles in normal physiological processes such as synaptic plasticity, learning, and memory. Substantial evidence indicates that NMDAR dysfunction, particularly excessive calcium influx, critica...

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Principais autores:	Keyi Zhang, Ming Wen, Xinyue Nan, Shuaizhu Zhao, Hao Li, Yanping Ai, Houze Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-07-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	NMDA receptors (N-methyl-D-aspartate receptors) neurodegenerative disease excitotoxicity glutamate Alzheimer’s disease (AD) Huntington’s disease (HD)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1604378/full
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