Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling

Bile salts accumulating during cholestatic liver disease are believed to promote liver fibrosis. We have recently shown that chenodeoxycholate (CDC) induces expansion of hepatic stellate cells (HSCs) in vivo, thereby promoting liver fibrosis. Mechanisms underlying bile salt-induced fibrogenesis rema...

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Autori principali:	Sebastian Zimny, Dennis Koob, Jingguo Li, Ralf Wimmer, Tobias Schiergens, Jutta Nagel, Florian Paul Reiter, Gerald Denk, Simon Hohenester
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-07-01
Serie:	Cells
Soggetti:	cholestasis HSC myofibroblast chenodeoxycholate phosphatidyl-inositol-3-kinase p110 alpha Alpelisib
Accesso online:	https://www.mdpi.com/2073-4409/11/15/2344
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