Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling

Bile salts accumulating during cholestatic liver disease are believed to promote liver fibrosis. We have recently shown that chenodeoxycholate (CDC) induces expansion of hepatic stellate cells (HSCs) in vivo, thereby promoting liver fibrosis. Mechanisms underlying bile salt-induced fibrogenesis rema...

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Ngā kaituhi matua:	Sebastian Zimny, Dennis Koob, Jingguo Li, Ralf Wimmer, Tobias Schiergens, Jutta Nagel, Florian Paul Reiter, Gerald Denk, Simon Hohenester
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2022-07-01
Rangatū:	Cells
Ngā marau:	cholestasis HSC myofibroblast chenodeoxycholate phosphatidyl-inositol-3-kinase p110 alpha Alpelisib
Urunga tuihono:	https://www.mdpi.com/2073-4409/11/15/2344
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!