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mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine

BackgroundThe new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS-CoV-2 and code for its spike (S) protein. Several studies have investigated short-term antibody (Ab) responses after vaccination.Objectiv...

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Principais autores: Jana Sophia Buhre, Tamas Pongracz, Inga Künsting, Anne S. Lixenfeld, Wenjun Wang, Jan Nouta, Selina Lehrian, Franziska Schmelter, Hanna B. Lunding, Lara Dühring, Carsten Kern, Janina Petry, Emily L. Martin, Bandik Föh, Moritz Steinhaus, Vera von Kopylow, Christian Sina, Tobias Graf, Johann Rahmöller, Manfred Wuhrer, Marc Ehlers
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-01-01
Serier:Frontiers in Immunology
Fag:
vaccination
antibody
SARS-CoV-2
COVID-19
IgG
IgG subclass
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020844/full
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