Structural modification of a novel inhibitor for mycobacterium enoyl-acyl carrier protein reductase assisted by In silico structure-based drug screening

Background: Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (mtInhA) is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls, and has been targeted in the development of anti-tuberculosis (TB) drugs. In our previous in silico structure-based dr...

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Autori principali:	Junichi Taira, Toshiki Nagano, Mitsuru Kitamura, Miho Yamaguchi, Hiroshi Sakamoto, Shunsuke Aoki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wolters Kluwer Medknow Publications 2020-01-01
Serie:	International Journal of Mycobacteriology
Soggetti:	enoyl-acyl carrier protein reductase gold program mycobacterium smegmatis mycobacterium tuberculosis structure-based drug screening
Accesso online:	http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=1;spage=12;epage=17;aulast=Taira
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