Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti‐GDF‐15 Antibody‐Based Combination Therapies

ABSTRACT Background In a recent Phase 2 trial in patients with cancer cachexia, the anti‐GDF‐15 antibody ponsegromab resulted in increased body weight, appetite, muscle mass and physical activity. This study provides compelling evidence that targeting the GDF‐15 pathway may offer a viable therapeuti...

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Detalhes bibliográficos

Principais autores:	Danna M. Breen, Stephanie Joaquim, Brianna LaCarubba Paulhus, Donald Bennett, Barbara Bernardo, Susie Collins, Ryan M. Esquejo, Ja Young Kim‐Muller, Laura Lin, Matthew Peloquin, Zhidan Wu, Shuxi Qiao, John C. Stansfield, Bei B. Zhang, Michelle I. Rossulek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-06-01
coleção:	Journal of Cachexia, Sarcopenia and Muscle
Assuntos:	cachexia GDF‐15 ghrelin mouse tumour models myostatin
Acesso em linha:	https://doi.org/10.1002/jcsm.70312
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