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Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti‐GDF‐15 Antibody‐Based Combination Therapies

ABSTRACT Background In a recent Phase 2 trial in patients with cancer cachexia, the anti‐GDF‐15 antibody ponsegromab resulted in increased body weight, appetite, muscle mass and physical activity. This study provides compelling evidence that targeting the GDF‐15 pathway may offer a viable therapeuti...

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Kaydedildi:
Asıl Yazarlar: Danna M. Breen, Stephanie Joaquim, Brianna LaCarubba Paulhus, Donald Bennett, Barbara Bernardo, Susie Collins, Ryan M. Esquejo, Ja Young Kim‐Muller, Laura Lin, Matthew Peloquin, Zhidan Wu, Shuxi Qiao, John C. Stansfield, Bei B. Zhang, Michelle I. Rossulek
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2026-06-01
Seri Bilgileri:Journal of Cachexia, Sarcopenia and Muscle
Konular:
cachexia
GDF‐15
ghrelin
mouse tumour models
myostatin
Online Erişim:https://doi.org/10.1002/jcsm.70312
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