Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury

Abstract Spinal cord injury (SCI) is a severe and multifaceted neurological trauma characterized by neuronal loss, axonal disruption, and limited regenerative potential, often causing lasting neurological deficits. Ferroptosis promotes neural cell death following SCI. The activation of glutathione p...

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Detalles Bibliográficos

Principais autores:	Baoyou Fan, Xiang Gao, Xiaoyang Chen, Xinjie Liu, Pengyu Wen, Yifei Ren, Boya Huang, Junjin Li, Ning Ran, Han Ding, Yiming Ren, Zhongju Shi, Chunyang Sun, Fengyu Wang, Yan Hao, Tao Liu, Guangzhi Ning, Xue Yao, Shiqing Feng
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-11-01
Series:	Journal of Nanobiotechnology
Assuntos:	Spinal cord injury Human umbilical cord mesenchymal stromal cell Exosome Ferroptosis GPX4 activator
Acceso en liña:	https://doi.org/10.1186/s12951-025-03755-7
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