Edaravone Modulates Neuronal GPX4/ACSL4/5-LOX to Promote Recovery After Spinal Cord Injury

The FDA-approved drug edaravone has a neuroprotective effect on spinal cord injury (SCI) and many other central nervous system diseases. However, its molecular mechanism remains unclear. Since edaravone is a lipid peroxidation scavenger, we hypothesize that edaravone exerts its neuroprotective effec...

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Detalhes bibliográficos

Principais autores:	Yilin Pang, Xinjie Liu, Xu Wang, Xuelian Shi, Lei Ma, Yan Zhang, Tiangang Zhou, Chenxi Zhao, Xu Zhang, Baoyou Fan, Jian Hao, Wenxiang Li, Xiaoqing Zhao, Rong Zhang, Songlin Zhou, Xiaohong Kong, Shiqing Feng, Xue Yao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-05-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	edaravone ferroptosis neuroinflammation neuroprotection spinal cord injury
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2022.849854/full
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