A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA

We recently showed that, after optimization, our methyl-CpG binding domain sequencing (MBD-seq) application approximates the methylome-wide coverage obtained with whole-genome bisulfite sequencing (WGB-seq), but at a cost that enables adequately powered large-scale association studies. A prior drawb...

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Detalles Bibliográficos

Principais autores:	Karolina A. Aberg, Robin F. Chan, Andrey A. Shabalin, Min Zhao, Gustavo Turecki, Nicklas Heine Staunstrup, Anna Starnawska, Ole Mors, Lin Y. Xie, Edwin JCG van den Oord
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2017-09-01
Series:	Epigenetics
Assuntos:	blood spots lab-technical optimization low-input dna methyl-cpg binding domain sequencing methylome-wide association study methylome-wide coverage whole-genome bisulfite sequencing
Acceso en liña:	http://dx.doi.org/10.1080/15592294.2017.1335849
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