Pseudorabies virus induces natural killer cell depletion by GSDMD-mediated inflammation and pyroptosis to promote infection and lung injury

ABSTRACT Pseudorabies virus (PRV) infection induces a hyperinflammatory response to promote inflammatory injury in multiple tissues. However, the relative mechanism remains elusive. Herein, we first confirmed that PRV infection could trigger pyroptosis to cause lung injury, evidenced by the increase...

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Detalhes bibliográficos

Principais autores:	Jing Chen, Guangming Zhao, Yi Yang, Yinhui Li, Yu Song, Daxia Li, Qian Du, Dewen Tong, Yong Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-08-01
coleção:	Journal of Virology
Assuntos:	pseudorabies virus lung injury NK cell
Acesso em linha:	https://journals.asm.org/doi/10.1128/jvi.00415-25
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