Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial

BackgroundAlarmins mediate type 2 T helper cell (Th2) inflammation and serve as upstream signaling elements in allergic inflammation and autoimmune responses. The alarmin interleukin (IL)-25 binds to a multi-domain receptor consisting of IL-17RA and IL-17RB subunits, resulting in the release of Th2...

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Үндсэн зохиолчид:	Guolin Xu, Sabina Paglialunga, Xuchen Qian, Ru Ding, Kenneth Webster, Aernout van Haarst, Caroline Engel, Chin Wai Hui, Lik Hang Lam, Weimin Li, Wai Chung Wu, Scott Rasmussen, Allen Hunt, Shui-on Leung
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2024-12-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	interleukin-17 receptor B interleukin-25 alarmins autoimmune diseases asthma humanized antibody
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495540/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!