A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs). Hepatic OCT1, intestinal OCT3, renal OCT2 on tubule basolateral membrane, and MATE1/2-K on tub...

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Autors principals:	Yiting Yang, Zexin Zhang, Ping Li, Weimin Kong, Xiaodong Liu, Li Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-05-01
Col·lecció:	Pharmaceutics
Matèries:	drug–drug interaction (DDI) metformin organic cation transporters (OCTs) physiologically based pharmacokinetic model (PBPK) multidrug/toxin extrusions (MATEs) pharmacokinetics
Accés en línia:	https://www.mdpi.com/1999-4923/13/5/698
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