Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts

Abstract Background In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome a...

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Detaylı Bibliyografya
Asıl Yazarlar:	Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie wyffels, Jan Detrez, Marlies Verschuuren, Winnok H. De Vos, Patrick Pauwels, Tim Van den Wyngaert, Sigrid Stroobants
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	SpringerOpen 2019-08-01
Seri Bilgileri:	EJNMMI Research
Konular:	[18F]HX4 PET CT Hypoxia Imaging biomarker Metformin
Online Erişim:	http://link.springer.com/article/10.1186/s13550-019-0543-4
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Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts

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