Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts

<p><b>Abstract</b></p> <p><b>Introduction</b></p> <p>Earlier, we showed that in cancer cells, AMP-activated kinase (AMPK) participates in a signal transduction pathway involving ATM-AMPK-p53/p21^cip1 which is activated by ionizing radiation (IR) to mediate G2-M arrest and enhanced cytotoxi...

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Detalhes bibliográficos

Principais autores:	Storozhuk Yaryna, Sanli Toran, Hopmans Sarah N, Schultz Carrie, Farrell Tom, Cutz Jean-Claude, Steinberg Gregory R, Wright James, Singh Gurmit, Tsakiridis Theodoros
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2012-05-01
coleção:	Radiation Oncology
Assuntos:	Lung cancer ATM p53 4-EBP1 p21<sup>cip1</sup>
Acesso em linha:	http://www.ro-journal.com/content/7/1/71
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