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Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological intervention of GIPR, however, has limited success...

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Principais autores: Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
coleção:mAbs
Assuntos:
GIPR
antagonistic antibody
crystallography
structure
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2019.1710047
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