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Handling missing values in patient-reported outcome data in the presence of intercurrent events

Abstract Introduction As patient-reported outcomes (PROs) are increasingly used in the evaluation of medical treatments, it is important that PROs are carefully analyzed and interpreted. This may be challenging due to substantial missing values. The missingness in PROs is often closely related to pa...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Doranne Thomassen, Satrajit Roychoudhury, Cecilie Delphin Amdal, Dries Reynders, Jammbe Z. Musoro, Willi Sauerbrei, Els Goetghebeur, Saskia le Cessie, on behalf of SISAQOL-IMI Work Package 3
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-03-01
Schriftenreihe:BMC Medical Research Methodology
Schlagworte:
Patient-reported outcomes
Missing data
Multiple imputation
Estimand
Intercurrent event
Repeated measurements
Online-Zugang:https://doi.org/10.1186/s12874-025-02510-8
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