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Estimands for clinical endpoints in tuberculosis treatment randomized controlled trials: a retrospective application in a completed trial

Abstract Background Randomized trials for the treatment of tuberculosis (TB) rely on a composite primary outcome to capture unfavorable treatment responses. However, variability between trials in the outcome definition and estimation methods complicates across-trial comparisons and hinders the advan...

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Autori principali: Isabelle R. Weir, Suzanne M. Dufault, Patrick P. J. Phillips
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-03-01
Serie:Trials
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Accesso online:https://doi.org/10.1186/s13063-024-07999-w
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