Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa

Pseudomonas aeruginosa is a high priority multi-drug-resistant (MDR) bacterial pathogen with increasing resistance against broad-spectrum antibiotics. Multiple efforts are ongoing to develop anti-pseudomonal vaccines however achieving meaningful outcomes has been challenging in human clinical trials...

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Autori principali:	Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R. Trachtman, Jacqueline D. Chu, David Custodio-Zegarra, Suman Bharti, Bhavya Bhardwaj, Shuangyi Bai, William T. Witt, Maria de la Paz Gutierrez, Sarah J. Miller, Kaitlyn Flowers, Trevor R. F. Smith, Bronwyn M. Gunn, Mariette Barbier, Elizabeth M. Parzych, David B. Weiner, Ami Patel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-07-01
Serie:	Frontiers in Immunology
Soggetti:	Pseudomonas aeruginosa PcrV complement system DNA-encoded monoclonal antibody type III secretion system
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618297/full
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