Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa

Pseudomonas aeruginosa is a high priority multi-drug-resistant (MDR) bacterial pathogen with increasing resistance against broad-spectrum antibiotics. Multiple efforts are ongoing to develop anti-pseudomonal vaccines however achieving meaningful outcomes has been challenging in human clinical trials...

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Principais autores:	Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R. Trachtman, Jacqueline D. Chu, David Custodio-Zegarra, Suman Bharti, Bhavya Bhardwaj, Shuangyi Bai, William T. Witt, Maria de la Paz Gutierrez, Sarah J. Miller, Kaitlyn Flowers, Trevor R. F. Smith, Bronwyn M. Gunn, Mariette Barbier, Elizabeth M. Parzych, David B. Weiner, Ami Patel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-07-01
Colecção:	Frontiers in Immunology
Assuntos:	Pseudomonas aeruginosa PcrV complement system DNA-encoded monoclonal antibody type III secretion system
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618297/full
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