Masking the transmembrane region of the amyloid β precursor protein as a safe means to lower amyloid β production

Abstract Introduction Reducing brain levels of both soluble and insoluble forms of amyloid beta (Aβ) remains the primary goal of most therapies that target Alzheimer's disease (AD). However, no treatment has so far resulted in patient benefit, and clinical trials of the most promising drug candidate...

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Hlavní autoři:	Ayesha Khan, Richard Killick, Daniel Wirth, Dominique Hoogland, Kalina Hristova, Jakob P. Ulmschneider, Christopher R. King, Martin B. Ulmschneider
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2023-10-01
Edice:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Témata:	Alzheimer's precursor protein amyloid beta molecular dynamics protein folding transmembrane domain
On-line přístup:	https://doi.org/10.1002/trc2.12428
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