GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-GlcNAc and plays a key role in metabolism, health, and aging. The HBP is controlled by its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFPT/GFAT) that is directly inhibited by UDP-GlcNAc in a fe...

詳細記述

書誌詳細

主要な著者:	Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2022-03-01
シリーズ:	eLife
主題:	hexosamine pathway AMDHD2 haploid mouse embryonic stem cells mutagenesis screen x-ray crystallography gfat2
オンライン･アクセス:	https://elifesciences.org/articles/69223
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