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GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-GlcNAc and plays a key role in metabolism, health, and aging. The HBP is controlled by its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFPT/GFAT) that is directly inhibited by UDP-GlcNAc in a fe...

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Автори: Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel
Формат: Artigo
Мова:Inglês
Опубліковано: eLife Sciences Publications Ltd 2022-03-01
Серія:eLife
Предмети:
hexosamine pathway
AMDHD2
haploid mouse embryonic stem cells
mutagenesis screen
x-ray crystallography
gfat2
Онлайн доступ:https://elifesciences.org/articles/69223
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