Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
Abstract In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium channel TREK‐1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability to TREK‐1. In addition,...
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| Autors principals: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer Nature
2017-02-01
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| Col·lecció: | EMBO Molecular Medicine |
| Matèries: | |
| Accés en línia: | https://doi.org/10.15252/emmm.201606690 |
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