Mutagenesis of the Varicella-Zoster Virus Genome Demonstrates That VLT and VLT-ORF63 Proteins Are Dispensable for Lytic Infection

Primary varicella-zoster virus (VZV) infection leads to varicella and the establishment of lifelong latency in sensory ganglion neurons. Reactivation of latent VZV causes herpes zoster, which is frequently associated with chronic pain. Latent viral gene expression is restricted to the VZV latency-as...

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Autori principali:	Shirley E. Braspenning, Robert Jan Lebbink, Daniel P. Depledge, Claudia M. E. Schapendonk, Laura A. Anderson, Georges M. G. M. Verjans, Tomohiko Sadaoka, Werner J. D. Ouwendijk
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-11-01
Serie:	Viruses
Soggetti:	varicella-zoster virus VLT VLT-ORF63 CRISPR/Cas9 BAC mutagenesis
Accesso online:	https://www.mdpi.com/1999-4915/13/11/2289
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