Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α

Abstract Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two mouse models with global or cardiomyocyte-specific disruption o...

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Hlavní autoři:	Nicola M. Sergienko, Adam J. Trewin, Helen Kiriazis, Antonia J. A. Raaijmakers, Daniel G. Donner, Victoria C. Garside, Kelly A. Smith, James R. Bell, Kimberley M. Mellor, Lea M. D. Delbridge, Julie R. McMullen, Kate L. Weeks
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-11-01
Edice:	npj Metabolic Health and Disease
On-line přístup:	https://doi.org/10.1038/s44324-024-00033-2
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