Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation

The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as α1-adrenergic and M1-muscarinic receptors (α1R and M1R, respectively), at least partly via the reduction of membrane p...

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Autori principali:	Taeko Kubo, Wei-Guang Ding, Futoshi Toyoda, Yusuke Fujii, Mariko Omatsu-Kanbe, Hiroshi Matsuura
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2015-01-01
Serie:	Journal of Pharmacological Sciences
Soggetti:	PI(4)P5-K HERG channel PI(4,5)P2 Gq protein-coupled receptors Arrhythmia
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1347861314000218
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