Multi-omics computational analysis unveils the involvement of AP-1 and CTCF in hysteresis of chromatin states during macrophage polarization

Macrophages display extreme plasticity, and the mechanisms and applications of polarization and de-/repolarization of macrophages have been extensively investigated. However, the regulation of macrophage hysteresis after de-/repolarization remains unclear. In this study, by using a large-scale compu...

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Principais autores:	Yubo Zhang, Wenbo Yang, Yutaro Kumagai, Martin Loza, Weihang Zhang, Sung-Joon Park, Kenta Nakai
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-12-01
Series:	Frontiers in Immunology
Assuntos:	macrophages macrophage hysteresis repolarization M1 macrophage M2 macrophage polarization memory
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1304778/full
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