In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling
SUMMARY The Ras oncogene contributes to ∼30% of human cancers, but alone is not sufficient for tumorigenesis. In a Drosophila screen for oncogenes that cooperate with an activated allele of Ras (RasACT) to promote tissue overgrowth and invasion, we identified the GTP exchange factor RhoGEF2, an acti...
Na minha lista:
| Principais autores: | , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists
2013-05-01
|
| Serier: | Disease Models & Mechanisms |
| Online adgang: | http://dmm.biologists.org/content/6/3/661 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|