Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin biased agonists

G protein-coupled receptors (GPCRs) are involved in essentially all physiological processes in mammals. The classical GPCR signal transduction mechanism occurs by coupling to G protein, but it has recently been demonstrated that interaction with β-arrestins leads to activation of pathways that are i...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Geisa A Santos, Diego A Duarte, Lucas T Parreiras-e-Silva, Felipe R Teixeira, Rafael M Silva-Rocha, Eduardo B Oliveira, Michel eBouvier, Claudio M Costa-Neto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	Signal Transduction Medicinal Chemistry GPCR biased agonism kinases.
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00131/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!