Advances in using PARP inhibitors to treat cancer
<p>Abstract</p> <p>The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with overall prognosis in...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2012-03-01
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| Serie: | BMC Medicine |
| Soggetti: | |
| Accesso online: | http://www.biomedcentral.com/1741-7015/10/25 |
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