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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca2+ release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively open. P...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xiaowei Hou, Ian R Outhwaite, Leanne Pedi, Stephen Barstow Long
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications Ltd 2020-11-01
Cyfres:eLife
Pynciau:
Mynediad Ar-lein:https://elifesciences.org/articles/62772
Tagiau: Ychwanegu Tag
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