Structural Lessons From the Mutant Proinsulin Syndrome
Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene (INS). Such mutations cause pancreatic β-cell dysfunction due to toxic misfolding of a mutant proinsulin and impairment in trans of wild-type insulin secret...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2021-09-01
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| Серии: | Frontiers in Endocrinology |
| Предметы: | |
| Online-ссылка: | https://www.frontiersin.org/articles/10.3389/fendo.2021.754693/full |
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