Structural Lessons From the Mutant Proinsulin Syndrome
Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene (INS). Such mutations cause pancreatic β-cell dysfunction due to toxic misfolding of a mutant proinsulin and impairment in trans of wild-type insulin secret...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Endocrinology |
| Assuntos: | |
| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/fendo.2021.754693/full |
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