Induction of p21<sup>CIP1/WAF1 </sup>expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization
<p>Abstract</p> <p>HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21<sup>CIP1/WAF1 </sup>and p27<sup>KIP1</sup>. Tax increases p27<sup>KIP1 </sup>protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causin...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BMC
2009-04-01
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| Serija: | Retrovirology |
| Online dostop: | http://www.retrovirology.com/content/6/1/35 |
| Oznake: |
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