Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans

Highlights Women showed higher percentage of IRF5 positive B cells compared to men. After stimulation with a TLR7 or TLR9 agonist, women showed higher percentages of IRF5 positive B cells compared with those of men. B cells of women produced higher levels of TNF-α in response to TLR9 stimulation. IR...

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Autores principales:	Claudia Beisel, Ana Jordan-Paiz, Sandra Köllmann, Annika Elise Ahrenstorf, Benedetta Padoan, Tanja Barkhausen, Marylyn M. Addo, Marcus Altfeld
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-02-01
Colección:	Biology of Sex Differences
Materias:	B cells Interferon regulatory factor 5 Sex differences Toll-like receptor 7/9 Tumor necrosis factor-α
Acceso en línea:	https://doi.org/10.1186/s13293-023-00495-x
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