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The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis

Abstract Background The prognosis of esophageal adenocarcinoma (EAC) and gastric adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently needed. Claudin 6 (CLDN6) is an oncofetal antigen that is largely absent in healthy tissues and upregulated in several cancers, making it a...

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Principais autores: Adrian Georg Simon, Su Ir Lyu, Mark Laible, Stefan Wöll, Özlem Türeci, Uğur Şahin, Hakan Alakus, Luca Fahrig, Thomas Zander, Reinhard Buettner, Christiane Josephine Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-08-01
coleção:Journal of Translational Medicine
Assuntos:
Adenocarcinoma
CAR T-cell therapy
Immunotherapy
Claudin
CLDN6
Tight junctions
Acesso em linha:https://doi.org/10.1186/s12967-023-04433-8
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