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The low complexity linker of DNAJB6b is key to its anti-amyloid function

Neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-independent manner. The molecular basis of this process is, ho...

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Auteurs principaux: Timas Merkelis, Ulf Olsson, Sara Linse
Format: Artigo
Langue:Inglês
Publié: Cambridge University Press 2025-01-01
Collection:QRB Discovery
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Accès en ligne:https://www.cambridge.org/core/product/identifier/S2633289225100161/type/journal_article
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