The low complexity linker of DNAJB6b is key to its anti-amyloid function

Neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-independent manner. The molecular basis of this process is, ho...

Descripción completa

Detalles Bibliográficos

Autores principales:	Timas Merkelis, Ulf Olsson, Sara Linse
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cambridge University Press 2025-01-01
Colección:	QRB Discovery
Materias:	amyloid inhibition chaperone activity protein aggregation protein folding low-complexity region
Acceso en línea:	https://www.cambridge.org/core/product/identifier/S2633289225100161/type/journal_article
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!