Identification of RPGRIP1L as an instability-maintaining gene to drive tumor growth and PD-L1 expression via Hedgehog signaling in breast cancer

Abstract Genomic instability is a hallmark of nearly all human cancers, yet the genetic regulators that govern this instability, their functional roles, and their therapeutic potential remain incompletely understood in breast cancer. In this study, we conducted a comprehensive analysis of the expres...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Meng Lv, Yan’e Liu, Weihong Cao, Yongmei Wang, Qi Wang, Xueqiang Gao, Baowei Peng, Haibo Wang, Yan Mao
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2025-12-01
Σειρά:	BMC Cancer
Θέματα:	Breast cancer Genome instability Hedgehog signaling Immune checkpoints RPGRIP1L
Διαθέσιμο Online:	https://doi.org/10.1186/s12885-025-15500-2
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