CIRBP Stabilizes <i>Slc7a11</i> mRNA to Sustain the SLC7A11/GPX4 Antioxidant Axis and Limit Ferroptosis in Doxorubicin-Induced Cardiotoxicity

Doxorubicin-induced cardiotoxicity (DIC) significantly constrains the clinical efficacy of anthracycline chemotherapy, primarily through the induction of ferroptosis, an iron-dependent, regulated cell death driven by oxidative stress and lipid peroxidation. However, the upstream regulators of ferrop...

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Detalhes bibliográficos

Principais autores:	Yixin Xie, Yongnan Li, Yafei Xie, Jianshu Chen, Hong Ding, Xiaowei Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-07-01
Colecção:	Antioxidants
Assuntos:	CIRBP doxorubicin oxidative stress cardiotoxicity ferroptosis SLC7A11
Acesso em linha:	https://www.mdpi.com/2076-3921/14/8/930
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