Structural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5’ UTR of the viral genome

ABSTRACT Non-structural protein 3 (Nsp3) is the largest open reading frame encoded in the SARS-CoV-2 genome, essential for the formation of double-membrane vesicles (DMV) wherein viral RNA replication occurs. We conducted an extensive structure-function analysis of Nsp3 and determined the crystal st...

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Detalhes bibliográficos

Principais autores:	Sofia Lemak, Tatiana Skarina, Deepak T. Patel, Peter J. Stogios, Alexei Savchenko
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-08-01
coleção:	Microbiology Spectrum
Assuntos:	SARS-CoV-2 virology structural biology RNA binding protein-protein interactions
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.02871-24
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