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Protrudin acts at ER-endosome contacts to promote KIF5-mediated endosomal tubule fission

Defective endosomal sorting and trafficking are increasingly recognised as key drivers of neurodegeneration, including hereditary spastic paraplegia (HSP) and other motor neuron disorders. Early endosomal tubule fission (ETF) is essential for sorting cargoes for recycling and retrograde transport, y...

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Wedi'i Gadw mewn:
Prif Awduron: Julia Kleniuk, Aishwarya G. Nadadhur, Catherine Rodger, Emily Wolfenden, Isabelle A. Hall, Samuel R. Cheers, Eliska Zlamalova, Evan Reid
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2026-01-01
Cyfres:Neurobiology of Disease
Pynciau:
Endosomal sorting
Endosomal tubule fission
Endoplasmic reticulum
Organelle contacts
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S0969996125004486
Tagiau: Ychwanegu Tag
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