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3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay

Abstract Background Most high-throughput screening (HTS) systems studying the cytotoxic effect of chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture that does not recapitulate the tumor microenvironment (TME). Tumor spheroids, however, can recapitulate the TM...

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Autori principali: Zhenzhong Chen, Seokgyu Han, Arleen Sanny, Dorothy Leung-Kwan Chan, Danny van Noort, Wanyoung Lim, Andy Hee-Meng Tan, Sungsu Park
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-01-01
Serie:Journal of Nanobiotechnology
Soggetti:
HER2-CAR T cell
3D hanging spheroid plate
Tumor spheroid
Cytotoxicity assay
Accesso online:https://doi.org/10.1186/s12951-021-01213-8
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